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Arabic :
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تقييم حالة الأكسدة و بعض العناصر الكلينيكوباثولوجية والوراثية الخلوية في الأبقار الحلابة المعرضة للعليقة الملوثة بالأفلاتوكسين (ب1) والزيرالينون
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| Abstract |
Summary
The objective of this study was to evaluate the effect of aflatoxin B1 and zeralenone on oxidant /antioxidant balance, liver function in addition chromosomal abnormalities in dairy cows. A total number of 33 dairy multiparous Holstien Friesian lactating cows were under investigation, their body weight ranged from 650-750 kg .Cows were classified into two groups ,control group (n=11) received ration where aflatoxin B1and zearalenone concentrations not exceed the permissible limits.While the other group(n=22) fed ration contaminated with aflatoxin B1and zearalenone mycotoxins.Three blood samples were taken from each cows .The first used for serum separation and the obtained sera were used for determination of copper and zinc ,liver enzymes (ALT-AST) ,urea and creatinine .The second sample for plasma separation and estimation of enzymatic antioxidant activities (glutathione peroxidase ,superoxide dismutase and catalase ) and malondialdehyde.While the third blood sample used for cytogenetic analysis.The obtained results of the second group showed that there were significant imbalance in most of oxidant /antioxidant parameters (significant decrease in glutathione peroxidase ,superoxide dismutase and catalase on contrary significant increase in malondialdehyde) . Copper and zinc statistically non significant decrease. Additionally, liver enzymes and urea showed significant increase while statistically non significant decrease recorded in level of serum creatinine. Concerning cytogenetic change, the same group revealed significant increase in numerical aberrations (peridiploidy) and structural aberrations (deletion, fragments) in addition to gonosomal anomalies (59-xo).Generally, the total percent of aberrated cells was significantly increase
In conclusion, aflatoxin B1and zearalenone contaminated ratio cause a harmful effects on redox status ,liver function, in addition to their adverse effect on chromosomal abnormalities which reflect negatively on farm production and economy.
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| Publication year |
2011
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| Pages |
5-19
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| Availability location |
المجلة
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| Availability number |
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| Organization Name |
Animal Reproduction Research Institute (ARRI)
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| Author(s) from ARC |
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| Agris Categories |
Animal physiology and biochemistry
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| Publication Type |
Researsh & Applied Activities
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