| Titles |
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English :
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Investigation Of The Antiviral Effect of Ribavrin and Acyclover on Canine Distemper and Infectious Canine Hepatits Viruses
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Arabic :
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استبيان تأثير الريبافيرين و الأيكلوفير كمضادات للفيروسات علي فيروسي الديستمبر و الإالتهاب الكبدي الوبائي في الكلاب
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| Abstract |
Investigation the cytotoxic and antiviral effects of Ribavirin on Vero cells, it was found that ribavirin is a safe for Vero cells where neither growth inhibition nor cell toxicity have been recorded and a potent ant-canine distemper virus with all used concentration (0.1, 1.5; 10:100 and 200 µg/ml). It was found that all vaccinated puppies with canine distemper vaccine did not show any abnormal clinical signs except 3 of them showed slight rise in rectal temperature (38.5-39oC) on the 2nd day post vaccination returned to its normal level (7-37.5oC) by the treatment with a dose of 200 µg of ribavirin injected intramuscularly for 3 successive days. Also it was noticed that treatment of experimentally infected puppies with canine distemper revealed that the dose of 10ug/ animal did not cure the disease completely where 2 puppies had progressed clinical signs of canine distemper like the untreated one while 100 and 200 µg/ animal resulted in complete curing of infected animals.
In addition, in vitro studies revealed that all tested concentration of Acyclovir were found to be safe for Vero cell showing no cell toxicity and did not affect the cell growth Kinetics. On the other side it was noticed that complete antiviral effect of Acyclovir against CAV-1 was obtained by the use of concentrations of 200 µg/ml/100 TCID50 of the virus. Vaccination of puppies with the live attenuated canine hepatits vaccine resulted in rise rectal temperature, diarrhea and corneal opacity in 2 puppies while the other 8 vaccinated puppies did not show any abnormal clinical signs.
So it could be concluded that ribavirin and acyclovir could be used as anticanine distemper and anti-canine hepatitis respectively either in cases of post vaccination or post infection.
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| Publication year |
2008
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| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
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| City |
suez
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| serial title |
5th scientific conference
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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| Publication Type |
Conference/Workshop
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