| Titles |
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English :
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Studies on some physilolgical responses of male and female local chicks to the antioestrogenic drug tamoxifen
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Arabic :
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دراسات على بعض الاستجابات الفسيولوجية لاناث و ذكور الكتاكيت المحلية للعقار المضاد للاستروجين التاموكسيفين
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| Abstract |
A total of 1528 Gimmizah chicks were used in the present study and divided into four main groups: A, B, C and D according to age to investigate the response of birds to tamoxifen (TAM) injection at doses of 0,0.5,5.0 and 10.0 mg/kg.Bw. Group A started receiving TAM injections at the age of one week, meanwhile, the other three groups B, C and D started TAM injections at the age of 5, 9 and 13 weeks consequently. Injections were applied intraperitoneally once each three days for six successive weeks.
Experimental results indicated that testes and oviduct relative weights were significantly increased due to TAM injections at doses of 0.5 mg, and 10 mg respectively, in group (A), but ovarian relative weights were not significantly affected with TAM injections.
No significant differences in plasma total lipids could be detected due to doses or sex of birds at the age of one week, but, TAM injection significantly increased plasma total lipids in group (C) and TAM 5 mg in group (B). In all groups plasma cholesterol and total lipids levels in females were higher than males.
TAM injection at any dose had not significant effect on estradiol levels. Plasma testosterone was significantly by reduced due to TAM 0.5 mg in groups (A and B), but, all TAM doses significantly increased plasma testosterone levels in group (D). TAM doses applied had not significantly affected spermatogensis in males, while, viability in TAM doses were significantly lower than control in group (A). Moreover, vitality was increased significantly due to TAMS mg in group (D). Chicks weight at hatch was the only trait that significantly by varied in groups (A and C), but, no significant differences among treatment could be detected for fertility, hatchability, pipped, late dead and early dead percentages.
Keywords: chicks, physiological, autioestrogenic, female.
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| Publication year |
2003
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| Pages |
719-734
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| Availability location |
معهد بحوث الانتاج الحيوانى- شارع نادى الصيد- الدقى- الجيزة
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| Availability number |
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| Organization Name |
Animal Production Research Institute (APRI)
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| serial title |
Egyptian Journal Agricultural Research
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| ISSN |
1110-6336
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| Author(s) from ARC |
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| External authors (outside ARC) |
محمد مصطفى الحباك
جامعة كفر الشيخ
نعمت عبد الغنى بدوى
جامعة كفر الشيخ
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| Agris Categories |
Animal physiology - Nutrition
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AGROVOC
TERMS |
Chicks.
Females.
Males.
Physiological functions.
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| Proposed Agrovoc |
autioestrogenic;tamoxifen;ovarian relative weights;ovarian relative weights;
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| Publication Type |
Journal
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