| Titles |
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English :
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The use of animal models other than dogs to test the potency of canine parvo vaccine
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Arabic :
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استخدام نماذج حيوانات غير الكلاب لإختبار كفاءة بارفو الكلاب.
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| Abstract |
An inactivated canine parvo vaccine was inoculated by different doses and "methods subcutaneous and intreritoneal" in hamster Guinea pigs and rats as animal model for potency test in addition to dogs. It was found that rat was the suitable animal for such purpose when inoculated with 1 ml of the vaccine subcutaneously exhibition the highest titer of serum neutralizing antibodies on the 3rd week post vaccination (1.5 log 10) and 1.66 antibody titer of ELISA in Guinea pigs, these antibody titers reached 1.2 log10 and 1.45 by serum neutralization test and ELISA respectively by using a dose of 2 ml of vaccine. These results came in parallel to those obtained by vaccination of puppies.
So, rat could be used as an animal model for potency test of canine parvo vaccine instead of dogs.
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| Publication year |
2008
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| Pages |
42-426
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| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
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| City |
القاهرة
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| serial title |
the 5th scientific congress
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| Author(s) from ARC |
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| External authors (outside ARC) |
نرمين جودة شفيق
المعمل المركزي للرقابة علي المستحضرات
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| Agris Categories |
Animal diseases
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| Publication Type |
Conference/Workshop
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