| Titles |
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English :
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Synthesis DNA Binding and antiviral activity of new uracil, xanthine and pteridine Derivatives
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| Abstract |
Some of new 6-amino-1,3- dimethy1-5 (substituted methylidene) aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one – carbon source to afford 1,3 dime-thy1-6 substituted pteridine derivatives. Certain uracils gave xanthine instead of the expected pteridine derivatives upon using another one- carbon source such as triethy1 orthoacetate or triethy1 orthobenzoate. The nucleic acid binding assay revealed that some new compounds showed high affinity, chelation, and fragmentation of nucleic acids whether DNA or RNA contrary to acyclovir that has affinity to DNA only. The antiviral activity of these novel compounds showed that compounds 2e and 2f reduced the cytopathogencity of peste des petits ruminant virus (PPRV)on Vero cell culture by 60 and 50% respectively.
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| Publication year |
2007
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| Pages |
26-31
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| Availability location |
ش السكة البيضاء - العباسية -القاهرة
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| Availability number |
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| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
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| serial title |
Archive der pharmazie chemistry in life sciences
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| ISSN |
0365-6233
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Antiviral agents.
Binding proteins.
DNA.
Uracil.
Xanthines.
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| Publication Type |
Journal
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