| Titles |
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English :
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Effect of Some Natural Antioxidants on Ox sterol Formed Endogenously in Hypercholesterolemia Rats
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Arabic :
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تأثير بعض مضادات الاكسده الطبيعيه على الاوكسيستيرول المتكونة داخليا في الفئران مرتفعة الكولستيرول
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| Abstract |
This study investigated the effect of selenium (15 µg/ 100g rat/d as sodium selenite), lyophilized green tea extract (0.12 g/100g rat/d), lyophilized anthocyanins pigment of red grape marc extract (0.71 mg/100g rat/d), and lyophilized -carotene pigment of carrot pulp waste extract (5 mg/100g rat/d) as antioxidants on the oxysterols in plasma, brain and liver formed endogenously in hypercholesterolemic rats exposed to H2O2 (1%). Rats were fed hypercholesterolemic diet and exposed to H2O2-induced oxidative stress for 9 weeks. The concentrations of cholesterol and cholesterol oxidation products (COP) (25-hydroxycholesterol, 7β-hydroxycholesterol and 7- ketocholesterol), were significantly increased in plasma and organs (brain & liver), and significantly reduced by antioxidant treatment, but the lowered values were still higher than that found in normal group. Plasma malondialdehyde (MDA) and lactic acid dehydrogenase activity (LDH) were significantly increased, while the activity of superoxide dismutase (SOD) and catalase (CAT) activity were decreased in hypercholesterolemic rats. The administrated antioxidants returned these values to the normal levels or near.
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| Publication year |
2008
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| Availability location |
معهد بحوث تكنولوجيا الأغذية
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| Availability number |
مركز البحوث الزراعية - ش الجامعه - الجيزة
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| Organization Name |
Food Technology Research Institute (FTRI)
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| Author(s) from ARC |
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| External authors (outside ARC) |
سمير عبد المنعم اسماعيل
كلية الزراعة - جامعة القاهرة - قسم كيمياء حيوية
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| Agris Categories |
Diet and diet-related diseasesHuman nutrition - General aspectsNutrition programmes
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AGROVOC
TERMS |
Antioxidants.
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| Publication Type |
Journal
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