| Titles |
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English :
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Elaborate on the role of cellular and humoral immune responses in protection against fowl cholera
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Arabic :
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استيضاح دور المناعة الخلوية والسائلة في الحماية ضد مرض كوليرا الطيور
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| Abstract |
In a trial to elaborate on the role of both cell-mediated and humoral immune responses in chickens vaccinated against fowl cholera; 5 groups, each of 40 chicken were used for the study undertaken. The first two of them were vaccinated at their 6th week of age and boostered three weeks later; one group with a live pasteurella multocida vaccine and the other with an inactivated one. The second 2 groups were cyclophosphamide-treated intramuscularly within their first day of age for depletion of B-lymphocytes and exclude the humoral immune response and thereafter vaccinated and boostered as mentioned above, one group, with the live vaccine and the other with the inactivated one. The 5th group was held as an unvaccinated untreated group. Results revealed that cyclophosphamide suppressed the induction of any humoral immune response, and didn’t influence the provoking of the cell mediated one.
Both live & inactivated P.multocida vaccines evoked the usually expected levels of cell-mediated immune responses, in that, response to live vaccine was significantly higher than that to the inactivated one (p<0.05). Percent protection, 3 weeks post initial vaccination against a virulent challenge P.multocida organism was 90&70, respectively for both live & inactivated vaccines in C cyclophosphamide – untreated birds, whereas it was 25 &15, respectively for treated birds. It was 90% for both vaccines; 2 weeks post boostering in untreated groups where it was 40&25, respectively in treated ones. The difference in the percentage of protection summarizes the role of humoral immune response in protection against P.multocida.
It could be concluded that both humoral and cellular immune responses are indispensable to achieve a significant levels of protection through vaccination against fowl cholera.
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| Publication year |
2006
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| Availability location |
معهد بحوث الامصال واللقاحات البيطرية.
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| Availability number |
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| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
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| City |
الغردقة
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| serial title |
المؤتمر الثامن لكلية الطب البيطري- جامعة الزقازيق
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| Author(s) from ARC |
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| External authors (outside ARC) |
حامد جمال الدين
معهد بحوث الأمصال واللقاحات البيطرية
منير الصفتي
المعمل المركزي للرقابة على المستحضرات الحيوية
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Fowl cholera.
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| Proposed Agrovoc |
p.multocida;
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| Publication Type |
Conference/Workshop
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