| Titles |
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English :
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Trials for production of inactivated fowl pox vaccine from the local isolate
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Arabic :
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محاولات لإنتاج لقاح مثبط ضد مرض جدري الطيور من العترة المحلية
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| Abstract |
The inactivated fowl pox vaccines (PFV) were prepared from a virulent local isolate. The inactivation process of the virus was applied by using formalin and binary ethyleneimine (BEI) with different concentration and at different time intervals. Inactivation of FP Virus with formalin was applied with different concentration (0.5%, 1%, 2%) and incubated for 24 hours virus infectivity was tested every 2 hours. The best condition for inactivation of FPV with BEI was done using 1% 2% 3% concentrations incubated for 24 hours, virus infectivty was tested every one hour intervals. The virus was completely inactivated with 1 % BEL after 18 hr. incubation the inactivated virus was adsorbed on aluminium hydroxide gel in a ratio of 1:1 and incubated for 6 hours. BEI inactivated FPV vaccine was better than formalin inactivated one due to the full inactivation efficiency of BEI. The antibody levels of vaccinated chickens were investigated by serum neutralization test which appeared from the 1st week post vaccination and reached its peak on the 3rd week. The prepared vaccines which proved to be sterile, safe and potent could be used in field for vaccination of layers which could not be vaccinated with live vaccine to avoid post vaccinal reaction which decrease or stop in egg production. And also used during epidemic with another inactivated vaccine as a combined vaccine
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| Publication year |
2006
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| Availability location |
معهد بحوث الامصال و اللقاحات البيطرية
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| Availability number |
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| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
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| City |
السويس
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| serial title |
مجلة طب بيطري قناة السويس- كلية الطب البيطري-جامعة قناة السويس
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| ISSN |
1110-6298
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Avipoxvirus.
Vaccines.
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| Publication Type |
Journal
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