| Titles |
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English :
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Biochemical and pathological studies of the effect of a chemical carcinogen Dimethy initrosamine ( DMN ) in mice
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Arabic :
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دراسة بيوكيميائية وباثولوجية على التأثير الكيميائى المسرطن داى ميثيل نيتروزامين على الجرذان
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| Abstract |
One hundred and twenty mice 1-1.5 month old were divided into 4 separate groups ( 30 mice each ) ./the first three groups were injected intraperitoneally with a single dose of a chemical alkylating hepatocarcinogen ( dimethyInitrosamine ) at 10.5 and 2.5 mg/kg body weight respectively . the fourth group was kept as a control . three mice from each group were sacrificed at monthly intervals and serum samples and tissue specimens were collected for40 weeks .biochemical analysisevealed dose and time dependent significant decrease in total protein and albumin increased activities of Alanine-aminotransferase ( ALT ) Aspartate aminotransferase( AST ) and alkaline phosphatase ( ALP ) and fetoprotein pathological studies revealed various changes in the liver of treated mice including altered foci of hepatocytes as pre-neoplastic lesions after 8 weeks benign hepatoma at12-24 weeks well different hepatocellular carcinoma at 28-36 weeks and poorly different hepatocellular carcinoma at 40 weeks of treatment . hepatocarcinogenesis was detected in most of the treated mice meanwhile metastasis was recorded only in the group of time treated with the highest dose it was concluded that a single low dose of mice DMN is capable of tumour induction in the liver of mice
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| Publication year |
2002
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| Pages |
29-56
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| Availability location |
مكتبة معهد بحوث صحة الحيوان -ش نادى الصيد - الدقى
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| Availability number |
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| Organization Name |
Animal Health Research Institute (AHRI)
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| City |
القاهرة
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| serial title |
مجلة الجمعية المصرية للباثولوجيا المقارنة والباثولوجيا الاكلينكية
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| Author(s) from ARC |
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| Agris Categories |
Animal diseasesAnimal physiology and biochemistry
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AGROVOC
TERMS |
Biochemical reactions.
Mice.
Nitrosamines.
Pathology.
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| Publication Type |
Journal
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