| Titles |
|
English :
|
The effect of Freeze – Drying on the keeping
Quality of Anti – Tetanic Serum
|
|
Arabic :
|
دراسات علي تأثير التجفيد بالتبريد علي الجودة النوعيةللمصل المضاد للتيتانوس
|
|
| Abstract |
The purpose of this work is to obtain lyophilized preparation of tetanus antitoxin, and to study the effect of freeze – drying on the keeping quality of the lyophilized products. Six of antitetanic serum (ATS) products were prepared. These products were: liquid ATS with phenol 0.5% , lyophilized ATS with phenol 0.5%, liquid ATS with sodium azide 0.2% , lyophilized ATS with sodium azide 0.2% , lyophilized ATI with 0.2% sodium azide. Saccharose 1% and glycine 2% were used as stabilizer during lyophilized process.
Sterility, safety and potency tests were applied for evaluation of different prepared lyophilized products.
The results showed that the lyophilized products were easy re – constituted with distilled water. The products were prepared from ATS with sodium azide 0.2%, ATS with phenol 0.5% and their concentrated antitoxin immunoglobulin (ATI) were bacteriology, mycoplasma and fungal sterile, potent and safe for injection.
This study proved that the lyophilized process of the ATS either lyophilized as it is or lyophilized after concentration of antitoxin immunoglobulin has no effect on the sterility, safety and also has no significant effect of the freeze – dry products.
|
| Publication year |
2002
|
| Pages |
1373-1381
|
| Availability location |
معهد بحوث الامصال واللقاحات البيطرية
|
| Availability number |
|
| Organization Name |
Veterinary Serum and Vaccine Research Institute (VSVRI)
|
| City |
Cairo
|
| serial title |
Egypr J.Agric Res
|
| Author(s) from ARC |
|
| External authors (outside ARC) |
مجدي محفوظ عوض
معهد بحوث الأمصال واللقاحات البيطرية
|
| Agris Categories |
Animal diseases
|
| Proposed Agrovoc |
Anti-tetanic serum;التجفيد;
|
| Publication Type |
Journal
|