| Titles |
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English :
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The Protection Role of Nano-Doped Zinc Oxide on F2-Isoprostane as Biomarkers of Oxidative Stress in STZ- Induced Diabetic Retinopathy in Male Rats
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Arabic :
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دور الحماية لأكسيد الزنك النانوي على F2-isoprostane كمؤشر حيوي للأجهاد التاكسدي في اعتلال الشبكية السكري الناجم عن STZ في ذكور الجرذان
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| Abstract |
Oxidative stress (OS) has been suggested as one of basic mechanism behind the development of type 2 diabetes especially diabetic retinopathy (DR). Isoprostanes (IsoPs) are involved in type 2 diabetes and increased in pathological conditions associated with OS. Our present study was designed to prepare Cl: ZnO nano particles (Cl: ZnONPs) and evaluate the effect of ZnCl2 and Cl: ZnONPs at (5 and 10mg/kg bw) on retinal oxidative stress in STZ-induced diabetic rats. The male albino rats treated with one dose of streptozotocin (60mg/kg bw). The diabetic rats were administrated Zn Cl2 and Cl: ZnONPs (5 and 10mg/kg bw) orally for 3 days. The results investigated that TEM of Cl: ZnONPs has average particle size 14.5-70nm. Serum insulin and SOD were decreased and serum glucose and IsoPs were increased significantly (P?0.05) 72h after treatment with STZ (60mg/kg bw) than other groups. A significant decreased (P? 0.05) in glucose and F2- IsoPs levels and significant increase in insulin and SOD levels were detected also in retina in STZ diabetic rats which treated with ZnCl2 and Cl: ZnONPs (5 and 10mg/kg bw). Cl: ZnONPs (10mg/kg bw) + (60mg/kg bw) gave the best results compared to ZnCl2 (5 and 10mg/kg bw) + STZ and Cl: ZnONPs (5mg/kg bw) + STZ. In conclusion, Cl: ZnONPs have a highly protective effect against hyperglycemia and diabetic retinopathy oxidative stress, especially at (10mg/kg bw) dosage.
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| Publication year |
2020
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| Organization Name |
Food Technology Research Institute (FTRI)
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| serial title |
Journal of scientific and Technical Research
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| Author(s) from ARC |
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| Publication Type |
Journal
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