| Titles |
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English :
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Hepatoprotective activity of mulberry and cape gooseberry of thioacetamide induced liver injury in rats
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Arabic :
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التاثيرات الوقائية للتوت والحرنكش على كبد الفئران المصابة بالثيواسيتاميد
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| Abstract |
The present study to evaluate the hepatoprotective and antioxidant effects of black mulberry, white mulberry and cape gooseberry on the thioacetamide (TAA)-induced rats hepatocytes damage in vivo. In vitro study showed that significant differences in the total phenolics and total flavonoids content, between the black mulberry ,white mulberry and cape gooseberry. These findings revealed that black mulberry had more total antioxidant activity. The highest levels of glucose, fructose and arabinose were detected in white mulberry. The 54 male albino rats used in this study separated into nine groups of 6 rats each group for 4 weeks as follows: Group 1 served as a normal control. Groups 2-9: Rats injected with TAA (100 mg/kg, i.p.) twice a week. Group 2 kept as positive control. Groups 3, 4 were given 7.65 and 15.3g/kg black mulberry. Group 5,6 were administered 10 and 20 g/Kg white mulberry. Groups 7,8 received 6.65 and 13.3 g/Kg cape gooseberry. Finally, Group 9 was treated daily with silymarin (100 mg/kg). The effects were compared with a known hepatoprotective agent, silymarin. Alteration in the morphological and the levels of biochemical markers of hepatic damage were studied in the groups. TAA has elevated the liver function, kidney function, lipid profile and MDA levels and reduced the serum levels of albumin, HDL cholesterol, and CAT. Treatment with black mulberry, white mulberry and cape gooseberry juices brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Histological examination of the liver tissues confirmed the hepatoprotective effect of fruits juices. These results were documented by the amelioration signs in rat’s hepatic architecture. Conclusion: This study demonstrated the ameliorative effects of black mulberry, white mulberry and gooseberry juices against TAA induced hepatotoxicity in rats.
Keywords:black mulberry ,whit mulberry ,cape gooseberry ,antioxidants,liver fibrous
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| Publication year |
2020
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| Pages |
101-112
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| Organization Name |
Food Technology Research Institute (FTRI)
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| serial title |
American Journal of Food and Nutrition
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| Author(s) from ARC |
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| Publication Type |
Journal
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